Name | Berberine Sulfate |
Synonyms | NSC 150444 UNII-69A4M9800W Berberine Sulfate siarczanuberberyny Berberine bisulfate Siarczanu berberyny BERBERINE SULFATE(RG) Acid berberine sulfate Berbamine sulphate acid Berberine hydrogen sulfate berberine hydrogen sulphate Berberine hydrogen sulphate 5,6-Dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium sulfate Benzo[G]-1,3-benzodioxolo[5,6-A]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, sulfate 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium hydrogen sulfate |
CAS | 633-66-9 |
EINECS | 211-196-4 |
InChI | InChI=1/C20H18NO4.H2O4S/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;1-5(2,3)4/h3-4,7-10H,5-6,11H2,1-2H3;(H2,1,2,3,4)/q+1;/p-2 |
Molecular Formula | C20H19NO8S |
Molar Mass | 433.43 |
Melting Point | 274-275 °C (decomp) |
Solubility | Soluble in water, slightly soluble in ethanol, insoluble in chloroform or ether. |
Appearance | Orange crystal |
Storage Condition | Inert atmosphere,Room Temperature |
MDL | MFCD00075789 |
Physical and Chemical Properties | Yellow needle-like crystals. No odor, extremely bitter taste. Mp274. Soluble in water (1:30) and ethanol. |
Hazard Symbols | Xn - Harmful |
Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | 36 - Wear suitable protective clothing. |
UN IDs | 1544 |
WGK Germany | 3 |
RTECS | DR9867000 |
Hazard Class | 6.1(b) |
Packing Group | III |
berberine sulfate | berberine sulfate is a yellow clear liquid. Belongs to the broad-spectrum antibacterial drugs. With broad-spectrum antibacterial effect, in vitro against a variety of gram-positive bacteria and gram-negative bacteria have antibacterial effect, including hemolytic Streptococcus, Staphylococcus aureus, Vibrio cholerae, meningococcus, Shigella, salmonella typhi and diphtheria and other strong role. The influenza Virus, Amoeba, Leptospira and some skin fungi also have a certain inhibitory effect. In vitro experiments confirmed that this product can enhance the phagocytosis of leukocytes and hepatic reticuloendothelial system. Shigella, hemolytic Streptococcus, Staphylococcus aureus and other easily to this product resistance. This product for a variety of sensitive bacteria and bacteria and virus mixed infection caused by various types of severe type Diarrhea, long diarrhea not only has a strong healing effect, the use of other drugs ineffective cases are especially suitable. And can be produced in the body of a variety of toxins quickly excreted in vitro, so as to achieve the therapeutic effect of the disease. Clinically used for: 1, a variety of severe Diarrhea, mixed bacterial and viral infectious dysentery, unexplained long-term Diarrhea, long-term diarrhea more than chronic illness. 2, Virus sex Diarrhea: Rotavirus Virus, Transmissibility gastroenteritis, epidemic Diarrhea caused by transient Vomit, followed by Diarrhea water samples, dehydration, feces yellow or green, depressed spirit, anorexia, emaciation and failure. 3, bacterial Diarrhea: piglets yellow, white dysentery, paratyphoid disease caused by elevated body temperature of 40-41 ℃, loss of energy, appetite, chills, discharge slurry, pasty gray-white or yellow feces (especially fishy smell), the disease gradually emaciated pigs, growth retardation, arch back, rough hair and other symptoms. 4, medium and large pigs: group or explosive Diarrhea, diarrhea caused by eating mildew feed. 5, livestock due to weather changes, four cold, nutrition, piglets hypoglycemia, excessive feeding of trace elements, parasites and other factors caused by intractable Diarrhea and dysentery. |
Use | used as mitochondrial fluorescent probe in biochemical research; Clinical use is antibacterial drug. Berberine sulfate is an isoquinoline alkaloid with chemopreventive properties. It is used for the preparation of derivatives active against leishmaniasis and malaria. antibacterials, which have inhibitory effects on shigella, Staphylococcus and Streptococcus |
production method | the plant Coptis chinensis, cortex phellodendri chinensis, ten great contributions or three needles are crushed and then extracted with dilute sulfuric acid and refined. |